I'm in the middle of one holiday (currently in Cyprus, staying at my sister's flat near Limassol, back in the UK on Monday) and I've already booked the next one (sort of).
The Venetial Resort Hotel Casino and a ticket for Microsoft's MIX08 conference in Las Vegas are now booked. Hotel is booked for the week 3rd March to 8th March, with the conference just taking up 2.5 days at the end of that week. I've never been to Las Vegas so looking forward to a couple of days R&R beforehand. I missed MIX07 last year because I'd booked Microsoft's PDC conference in L.A. for later that year but then they went and cancelled it, so this year I'm not taking any chances. The UK version of the MIX conference which I attended a few weeks ago here in London was a pale shadow of the US version of these things and it's better to go direct to the source, especially as they're usually timed to coincide with major new releases from Microsoft.
Will book flights when I get back to the UK (late on Sunday) - not sure at this stage whether I'll also be able to fit in a trip to Los Angeles as well.